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Usage of gabapentin:
Indeed, combinations therapy is often used in the management of neuropathic pain in clinical practice [65], and gabapentin using two or more agents with proven efficacy, and which have complementary actions, has the potential to enhance efficacy and reduce side effects (through lower dosing of the individual agents) [66] .
Only gabapentin a few high-quality clinical trials of combination therapy for neuropathic pain have been conducted, and therefore GRADE evaluation was inconclusive [3] .
Nevertheless, Gilron and colleagues reported that gabapentin used in combination with nortriptyline [67] or morphine [68] achieved better efficacy and at lower doses than when the gabapentin agents were used as monotherapy .
Thus, the ability gabapentin to use gabapentin together with the the other classes of evidence-based pharmacological therapies, provides clinicians with the scope to trial empirical combination therapy should monotherapy fail .
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