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(b) The long-lasting, slow-recovering depressor phase of clonidine is clearly dose-dependent and shows the following characteristics: (1) it is inhibited by pretreatment with reserpine or phentolamine; (2) it is absent in the spinal, pithed or decapitated animal; (3) it is elicited by injection clonidine of minute quantities (even 1/100 of the intravenous dose) administered directly into the central nervous system (intracisternal, intrahypothalamic or intraventricular injection, or infusion into the vertebral arteries) and (4) It is also accompanied by bradycardia which persists throughout the entire blood pressure response to clonidine .
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