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    It is a white to off-white powder which is soluble in tetrahydrofuran, sparingly differin soluble in ethanol, and practically insoluble in water .
    The molecular formula differin is C28 H28 O3 and molecular weight is 412 .
    differin Adapalene is represented by the following structural formula .
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    Biochemical and pharmacological profile studies have demonstrated differin that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris .
    Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not differin bind to the cytosolic receptor protein .

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