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Atypicals: Legionella pneumophilia Mechanism of Action: Inhibition of topoisomerase (DNA gyrase) enzymes, which levaquin inhibits relaxation of supercoiled DNA and promotes breakage of double stranded DNA .
Pharmacodynamics: Fluoroquinolones produce both concentration dependent (peak:MIC), levaquin and a combination of concentration and time-dependent killing (AUC:MIC) .
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