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However, bolus administration alone is not useful for managing persistent ventricular arrhythmias because lidocaine plasma levels fall rapidly below the therapeutic level due to rapid clearance from the central compartment, lidocaine and ventricular arrhythmias have been observed to return within 15 to 20 minutes after an injection . 30 The practical clinical approach is to give a bolus dose at the same time constant infusion is initiated, in order to achieve persistent lidocaine therapeutic levels from the onset of administration . 34 With this approach, it would be expected that an initial peak level would be present followed by a rapid decline to some lidocaine breastfeeding 23 lidocaine 7 tetracaine lidocaine a drug lidocaine zinc oxide lidocaine 10 minimal level, and followed then by a slow rise to plateau concentrations .
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