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Ivabradine and procoralan nome commerciale procoralan bula medicina net procoralan opakowania procoralan uses S 18982 metabolite exposures were measured following weight-based dosing and dose titration designed to reach a dose that enables a 20% heart rate reduction without inducing bradycardia and/or signs or symptoms related to bradycardia .
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Steady state exposures of ivabradine and S 18982 following maintenance doses in procoralan pediatric patients are similar to exposures achieved in adult heart failure patients given 5 mg BID .
NONCLINICAL TOXICOLOGY Carcinogenesis, Mutagenesis, Impairment of Fertility procoralan There was no evidence of carcinogenicity when mice and rats received ivabradine up to 104 weeks by dietary administration .
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