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While retinal degeneration was not diagnosed in pigmented mirapex rats treated for 2 years, a thinning in the outer nuclear layer of the retina was slightly greater in rats given drug compared with controls .
Evaluation of the retinas of albino mice, mirapex monkeys, and minipigs did not reveal similar changes .
The potential significance of this effect for humans has not been established, but cannot be disregarded because disruption of a mechanism benicar and weight gain benicar side effects benicar weight gain benicar hct dosage benicar 40 12.5 that is universally present in vertebrates (i . , disk shedding) may be involved [see Nonclinical mirapex Toxicology (13 .
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