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COX-2 selective inhibitors tramadolor had a more favorable gastrointestinal side effect profile than nonselective NSAIDs but are associated with an increased risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke [111–113] .
Finally, NSAIDs may provoke reaction of hypersensitivity in atopic patient (asthma, nasal polyps, and ultram side effects in dogs how long does tramadol hcl 50 mg last tramadol and tylenol 3 high rhinitis) .
ER formulations can tramadolor be particularly appropriate for longterm pain management in patients with multifactorial pain, such as OA .
Tramadol showed a lower potential abuse than other tramadolor centrally acting analgesics .
An optimized treatment strategy could postpone and/or prescribe lower doses tramadolor of traditional scheduled opioid analgesics .
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