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REVIA has not been shown to provide any naltrexone therapeutic benefit except as part of an appropriate plan of management for the addictions .
An opioid-free interval of a minimum of 7 to naltrexone 10 days is recommended for patients previously dependent on short-acting opioids . To reduce the risk of precipitated withdrawal in patients dependent on opioids, or exacerbation of a preexisting subclinical withdrawal syndrome, opioid-dependent patients, including those being treated for alcohol dependence, should be opioid-free (including tramadol) before starting REVIA naltrexone treatment .
Switching from Buprenorphine, Buprenorphine/Naloxone, or naltrexone Methadone .
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