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The pharmacokinetics of losartan and its active metabolite were also determined after IV doses of each component losartan with potassium valsartan zdravilo cozaar dizziness losartan 50 mg hidroclorotiazida hyzaar separately in healthy volunteers .
The volume of distribution of losartan and valsartan erektionsstörungen valsartan sigma losartan 100 mg dosis maxima hyzaar generic side the active metabolite is about 34 liters and 12 liters, respectively .
Total plasma clearance of losartan and the active metabolite is about 600 mL/min and 50 mL/min, respectively, with renal clearance of about 75 mL/min and 25 cozaar mL/min, respectively .
After single doses of losartan administered orally, about 4% of the dose is excreted unchanged in the urine and cozaar about 6% is excreted in urine as active metabolite .
Biliary cozaar excretion contributes to the elimination of losartan and its metabolites .
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