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These effects occurred when pregnant mice received oral doses of 1000 or 3000 mg/kg/day during organogenesis and in rats neurontin ne işe yarar gabapentin overdose gabapentin 300 mg weight loss gabapentin multiple given 500, 1000, or 2000 mg/kg prior to and during mating and throughout gestation .
gabapentine These doses are approximately 1 to 5 times the human dose of 3600 mg on a mg/m2 basis .
No effects were observed in pregnant mice given 500 mg/kg/day (approximately 1/2 of the daily human dose on a gabapentine mg/m2 basis) .
An increased incidence of gabapentine hydroureter and/or hydronephrosis was observed in rats given 2000 mg/kg/day in a fertility and general reproduction study, 1500 mg/kg/day in a teratology study, and 500, 1000, and 2000 mg/kg/day in a perinatal and postnatal study .
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