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blo vyavleno umenshenie ploshadi pod krivoy AUC pioglitazona na topamax 15%, bez izmeneniya maksimalnoy konцentraцii preparata .
eti izmeneniya ne bli topamax statisticheski znachimmi .
dlya aktivnogo gidroksimetabolita pioglitazona takje blo vyavleno snijenie maksimalnoy konцentraцii topamax i ploshadi pod krivoy AUC na 13% i na 16% sootvetstvenno, a dlya aktivnogo ketometabolita dannaya versiya instrukцii po mediцinskomu primeneniyu deystvitelna s 24 avgusta 2015 g .
blo vyavleno snijenie i maksimalnoy topamax webmd topamax depression topamax cause depression topamax 25 mg uses topamax generic name konцentraцii i ploshadi pod krivoy AUC na 60% .
klinicheskaya znachimost etix dannx ne topamax vyasnena .
pri odnovremennom primenenii paцientami preparata topamax topamaks® i pioglitazona, sleduet tshatelno kontrolirovat sostoyanie bolnogo dlya oцenki techeniya saxarnogo diabeta .
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