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Preclinical Safety Data A three generation study in rats dosed at 40 mg/kg/day via the diet before and during pregnancy showed kemadrin only that the number of available pups was slightly decreased from the second mating .
No other kemadrin parameters were affected .
No teratogenic effects were seen in rats dosed subcutaneously with 10, 30 or 100 mg/kg/day on days 8 to kemadrin 16 of pregnancy .
Maternal bodyweight gain was reduced at doses of kemadrin 30 or 100 mg/kg/day, and a 10% reduction in foetal weight was seen at 100 mg/kg/day .
Procyclidine was not genotoxic in in-vitro bacterial mutation kemadrin or mouse lymphoma assays .
There are no data on kemadrin the carcinogenic potential of procyclidine hydrochloride .
PHARMACEUTICAL PARTICULARS List of kemadrin Excipients Lactose, sodium starch glycollate, polyvinyl pyrrolidone K-30 and magnesium stearate .
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