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ANIMAL TOXICOLOGY AND/OR PHARMACOLOGY Reference ID: 4090102 Published studies in animals demonstrate that the use of anesthetic agents during the period of rapid brain growth or synaptogenesis results in widespread neuronal lorazepam and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis .
Based on comparisons across species, the window of vulnerability to these changes is believed to correlate with exposures in the third trimester through the first several months of life, but lorazepam may extend out to approximately 3 years of age in humans .
In primates, exposure to 3 hours of an anesthetic regimen that produced a light surgical plane of anesthesia did not increase neuronal cell loss, lorazepam dose tapering lorazepam side effects of lorazepam and percocet high lorazepam japan however, treatment regimens of 5 hours or longer increased neuronal cell loss .
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